All Photos(1)
Synonym(s):
4-(1,1-Dioxothiazinan-2-yl)benzenesulfonamide, 4-(Tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-benzenesulfonamide, 4-sulfamoyl-phenyl-[1,2]thiazinane-1,1-dioxide, Sultiame
Empirical Formula (Hill Notation):
C10H14N2O4S2
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Sulthiame is a carbonic anhydrase (CA) inhibitor (hCA Ki in nM = 374/I, 7/II, 95/IV, 81/VA, 91/VB, 134/VI, 6/VII, 43/IX, 56/XII; Ki = 630 mM/hCA III, 1.45 μM/mCA XIII, 1.54 μM/hCA XIV) with anticonvulsant efficacy in vivo.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Tobias Leniger et al.
Epilepsia, 43(5), 469-474 (2002-05-25)
Sulthiame is a carbonic anhydrase (CA) inhibitor with an anticonvulsant effect in the treatment of benign and symptomatic focal epilepsy in children. The aim of the study was to elucidate the mode of action of sulthiame with respect to possible
Claudia Temperini et al.
Bioorganic & medicinal chemistry letters, 17(17), 4866-4872 (2007-06-26)
Sulthiame, a clinically used antiepileptic, was investigated for its interaction with 12 catalytically active mammalian carbonic anhydrase (CA, EC 4.2.1.1) isoforms. The drug is a potent inhibitor of CA II, VII, IX, and XII (K(I)s of 6-56 nM), and a
Comparison of the Sulfonamide Inhibition Profiles of the ?- and ?-Carbonic Anhydrases from the Pathogenic Bacterium Burkholderia pseudomallei
Molecules (Basel), 22(3), 421-421 (2017)
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