All Photos(1)
Synonym(s):
1-[2,4-Dichloro-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazole
Empirical Formula (Hill Notation):
C9H4Cl2F3N3
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
ClC1=C(C(Cl)=CC=C1N2C=CN=N2)C(F)(F)F
Biochem/physiol Actions
ARUK3001185 is a brain-penetrant, orally available, potent and selective carboxylesterase Notum inhibitor (IC50 = 6.7 nM) and Wnt signaling activator with no cross-reactivity toward panels of 39 serine hydrolases, 485 kinases (IC50 >10 μM), and 47 human off-target liabilities (IC50 >30 μM).
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit
Journal of medicinal chemistry, 65(10), 7212-7230 (2022)
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling
Journal of Medicinal Chemistry, 64(8), 4289-4311 (2021)
Small-molecule inhibitors of carboxylesterase Notum
Future medicinal chemistry, 13(11), 1001-1015 (2021)
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