All Photos(1)
Synonym(s):
3-amino-N-(aminoiminomethyl)-5-(dimethylamino)-6-(2-phenylethynyl)-2-pyrazinecarboxamide hydrochloride
Empirical Formula (Hill Notation):
C16H17N7O · xHCl
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CN(C1=C(N=C(C(N)=N1)C(NC(N)=N)=O)C#CC2=CC=CC=C2)C.[xHCl]
Biochem/physiol Actions
DMA-135 is a cell penetrant and potent inhibitor of human enterovirus 71 (EV71) translation and replication that targets the IRES domain of EV71. DMA-135 binds allosterically to EV71 SLII RNA and stabilizes ternary complex consisting of AUF1-SLII-DMA-135. Also, previous data indicate that DMA-135 exhibit comparable affinity to HIV-1-TAR and HIV-2-TAR.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
Nature Communications, 11(1), 4775-4775 (2020)
Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR
MedChemComm, 8(5), 1022-1036 (2017)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service