SML3530
DMA-135
≥98% (HPLC)
Synonym(s):
3-amino-N-(aminoiminomethyl)-5-(dimethylamino)-6-(2-phenylethynyl)-2-pyrazinecarboxamide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C16H17N7O · xHCl
CAS Number:
Molecular Weight:
323.35 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
CN(C1=C(N=C(C(N)=N1)C(NC(N)=N)=O)C#CC2=CC=CC=C2)C.[xHCl]
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Cell penetrant and potent inhibitor of human enterovirus 71 (EV71) translation and replication that targets the IRES domain of EV71
DMA-135 is a cell penetrant and potent inhibitor of human enterovirus 71 (EV71) translation and replication that targets the IRES domain of EV71. DMA-135 binds allosterically to EV71 SLII RNA and stabilizes ternary complex consisting of AUF1-SLII-DMA-135. Also, previous data indicate that DMA-135 exhibit comparable affinity to HIV-1-TAR and HIV-2-TAR.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
Nature Communications, 11(1), 4775-4775 (2020)
Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR
MedChemComm, 8(5), 1022-1036 (2017)
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