Skip to Content
Merck
CN
All Photos(1)

Key Documents

View All Documentation

Safety Information

SML3508

Sigma-Aldrich

Intepirdine

≥98% (HPLC)

Synonym(s):

3-(Phenylsulfonyl)-8-(1-piperazinyl)quinoline, 3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline, GSK 742457, RVT 101, SB-742457

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C19H19N3O2S
CAS Number:
607742-69-8
Molecular Weight:
353.44
MDL number:
MFCD12828872
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=S(C1=CC=CC=C1)(C2=CC3=C(N=C2)C(N4CCNCC4)=CC=C3)=O

InChI key

JJZFWROHYSMCMU-UHFFFAOYSA-N

Biochem/physiol Actions

Intepirdine (SB-742457) is a brain blood barrier penetrant, orally available, potent and selective serotonin receptor 6 (5-HT6) receptor antagonist that potentiate cognitive and the behavioral abnormalities of AD in laboratory set up. Intepirdine has failed to demonstrate statistically significant impact on cognition or dementia in phase III trials. Intepirdine promotes satiety.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

5-HT6 receptor agonist and antagonist improve memory impairments and hippocampal BDNF signaling alterations induced by MK-801
Brain Research, 1722, 146375-146375 (2019)
The 5-HT?C receptor agonist, lorcaserin, and the 5-HT? receptor antagonist, SB-742457, promote satiety; a microstructural analysis of feeding behaviour
Psychopharmacology, 233(3), 417-424 (2016)
5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease
Neurotherapeutics, 5(3), 458-469 (2008)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service