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SML3469

Sigma-Aldrich

ADH-1 trifluoroacetate

≥95% (HPLC)

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Synonym(s):
(ADH-1)c trifluoroacetate, Cyclic-N-Ac-CHAVC-NH2 trifluoroacetate, Cyclic-N-Ac-Cys-His-Ala-Val-Cys-NH2 trifluoroacetate, Exherin trifluoroacetate, N-Ac-CHAVC-NH2 (C1-C5 disulfide) trifluoroacetate, N-Ac-CHAVC-NH2 trifluoroacetate, N-Ac-Cys-His-Ala-Val-Cys-NH2 (Cys1-Cys5 disulfide) trifluoroacetate, c(N-Ac-CHAVC-NH2) trifluoroacetate, c(N-Ac-Cys-His-Ala-Val-Cys-NH2) trifluoroacetate
CAS Number:
229971-81-7
MDL number:
MFCD30207838
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

storage temp.

−20°C

InChI

1S/C22H34N8O6S2/c1-10(2)17-22(36)29-15(18(23)32)7-37-38-8-16(27-12(4)31)21(35)28-14(5-13-6-24-9-25-13)20(34)26-11(3)19(33)30-17/h6,9-11,14-17H,5,7-8H2,1-4H3,(H2,23,32)(H,24,25)(H,26,34)(H,27,31)(H,28,35)(H,29,36)(H,30,33)/t11-,14-,15-,16-,17-/m0/s1

InChI key

FQVLRGLGWNWPSS-BXBUPLCLSA-N

Biochem/physiol Actions

ADH-1 is an N-cadherin (CD325; NCAD) antagonist that selectively inhibits NCAD-dependent neurite outgrowth (IC50 = 323 μM; PN1-2 rat cerebral neurons on monolayer of chick NCAD-expressing 3T3), while exhibiting no effect against integrin receptor-dependent neurite outgrowth. ADH-1 inhibits NCAD-mediated signaling events in cultures (0.2-2.5 mg/mL) and exhibits anti-tumor efficacy in vivo (50-100 mg/kg i.p. in rats and mice).

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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