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IAXO 102 trifluoroacetate salt, Methyl 6-deoxy-6-amino-2,3-di-O-tetradecyl-α-D-glucopyranoside trifluoroacetate salt
C35H71NO5 · xC2HF3O2
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Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
storage temp.
-10 to -25°C
SMILES string
O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]1CN)OC)OCCCCCCCCCCCCCC)OCCCCCCCCCCCCCC.[xCF3CO2H]
Biochem/physiol Actions
IAXO-102 is a potent and selective toll-like receptor 4 (TLR4) antagonist that protect mice from LPS induced septic shock. IAXO-102 inhibits development of an experimental abdominal aortic aneurysm. It also prevents acute BBB disruption after experimental post-subarachnoid hemorrhage in mice.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development.
Atherosclerosis (2015)
Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization.
Journal of Medicinal Chemistry (2009)
Selective Toll-Like Receptor 4 Antagonists Prevent Acute Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in Mice.
Molecular Neurobiology (2019)
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