All Photos(1)
Synonym(s):
4,4′-(Dithiodicarbonothioyl)bis[morpholine], 4-Morpholinethiocarbonyl disulfide, Bis(4-morpholinethiocarbonyl) disulfide, Bis(oxydi-2,1-ethanediyl)-thiuram disulfide, Dimorpholinethiuram disulfide, JX 06, JX-06, NSC 402538
Empirical Formula (Hill Notation):
C10H16N2O2S4
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
InChI
1S/C10H16N2O2S4/c15-9(11-1-5-13-6-2-11)17-18-10(16)12-3-7-14-8-4-12/h1-8H2
InChI key
KKVYOWPPMNSLCP-UHFFFAOYSA-N
Biochem/physiol Actions
JX06 is a potent, PDK1-selective, covalent pyruvate dehydrogenase (PDH) kinase (PDHK, PDK) inhibitor (PDK1/2/3 IC50 = 49/101/313 nM; PDK4 IC50 >10 µM, IC50 >10 µM against >300 other kinases). JX06 inhibits cellular PDK substrate PDHA1 Ser293/232 phosphorylation, resulting in reduced aerobic glycolysis and cancer proliferation in cultures (1-10 µM) and in mice in vivo (40-80 mg/kg via daily i.p. injection; A549 & HT-29 xenografts). JX06 is shown to target PDK1 Cys240 for covalent modification.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
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