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SML3439

Sigma-Aldrich

IXA4

98% (HPLC)

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Synonym(s):
N-​Methyl-​N-​[2-​(4-​methylphenoxy)​ethyl]​-​4-​[(1-​oxo-​3-​phenoxypropyl)​amino]​-1H-​pyrazole-​1-​acetamide
Empirical Formula (Hill Notation):
C24H28N4O4
CAS Number:
Molecular Weight:
436.50
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(CN1N=CC(NC(CCOC2=CC=CC=C2)=O)=C1)N(C)CCOC3=CC=C(C=C3)C

Biochem/physiol Actions

IXA4 is a nontoxic, potent and highly selective IRE1-XBP1s signaling activator that induce ER proteostasis remodeling. IXA4 reduced Aβ levels and prevents APP-associated mitochondrial dysfunction in CHO7PA2 cells expressing the V717F APP (APPV717F) mutant.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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