All Photos(1)
Synonym(s):
(3S,4S,4aR,6R,11bS,11cS)-11c-Ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-6,4, CID 91895267
Empirical Formula (Hill Notation):
C20H22N2O
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
powder
optical activity
[α]/D 295 to 245°
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
Biochem/physiol Actions
Koumine is a major indole alkaloid isolated from poisonous plant Gelsemium elegans that exhibits anti-inflammatory and analgesic effects in inflammatory and neuropathic pain models. It appears that koumine ameliorate chronic constriction injury induced neurotic pain through induction of autophagy and the inhibition apoptosis in the spinal cord of rodents. Koumine protects IPEC-J2 cells from hydrogen peroxide induced oxidative stress and apoptosis through decreasing reactive oxygen species (ROS) production.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
WGK
WGK 3
Regulatory Information
监管及禁止进口产品
Certificates of Analysis (COA)
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Qiao Ye et al.
PloS one, 14(2), e0212231-e0212231 (2019-02-13)
Koumine is a component of the Chinese medicinal herb Gelsemium elegans and is toxic to vertebrates. We used the ciliate Tetrahymena thermophila as a model to evaluate the toxic effects of this indole alkaloid in eukaryotic microorganisms. Koumine inhibited T.
Gui-Lin Jin et al.
Frontiers in pharmacology, 9, 989-989 (2018-09-15)
Koumine, an indole alkaloid, is a major bioactive component of Gelsemium elegans. Previous studies have demonstrated that koumine has noticeable anti-inflammatory and analgesic effects in inflammatory and neuropathic pain (NP) models, but the mechanisms involved are not well understood. This
Zhihang Yuan et al.
International journal of molecular sciences, 20(3) (2019-02-14)
Medicinal herbal plants have been commonly used for intervention in different diseases and improvement of health worldwide. Koumine, an alkaloid monomer found abundantly in Gelsemium plants, can be effectively used as an antioxidant. The purpose of this study was to
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