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SML3413

Sigma-Aldrich

ASC-J9

≥98% (HPLC)

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Synonym(s):
(1E, 4Z, 6E)-5-Hydroxy-1,7-bis(3,4-dimethoxyphenyl)-1,4,6-heptatrien-3-one, Dimethylcurcumin, GO-Y025
Empirical Formula (Hill Notation):
C23H24O6
CAS Number:
52328-98-0
Molecular Weight:
396.43
MDL number:
MFCD28964095
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

, White to light orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

OC(/C=C/C1=CC(OC)=C(C=C1)OC)=C\C(/C=C/C2=CC(OC)=C(C=C2)OC)=O

InChI

1S/C23H24O6/c1-26-20-11-7-16(13-22(20)28-3)5-9-18(24)15-19(25)10-6-17-8-12-21(27-2)23(14-17)29-4/h5-15,24H,1-4H3/b9-5+,10-6+,18-15-

InChI key

ZMGUKFHHNQMKJI-CIOHCNBKSA-N

Biochem/physiol Actions

ASC-J9 (dimethylcurcumin) is an androgen receptor (AR)-selective degradation promoter that disrupts the interaction between AR and its coregulators. ASC-J9 induces AR degration in cultures (5 µM, LNCaP) and shows in vivo therapeutic efficacy (50 mg/kg i.p. qod) in murine bladder cancer (TCC-SUP and UMUC3 xenografts) and a spinal and bulbar muscular atrophy disease model (AR-polyQ transgenic SBMA mice).

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Hao Tian et al.
Journal of experimental & clinical cancer research : CR, 40(1), 3-3 (2021-01-05)
Early studies indicated that ASC-J9®, an androgen receptor (AR) degradation enhancer, could suppress the prostate cancer (PCa) progression. Here we found ASC-J9® could also suppress the PCa progression via an AR-independent mechanism, which might involve modulating the tumor suppressor ATF3

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