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Safety Information

SML3411

Sigma-Aldrich

LY2828360

≥98% (HPLC)

Synonym(s):

8-(2-Chlorophenyl)-2-methyl-6-(4-methyl-1-piperazinyl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine, LY 2828360

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About This Item

Empirical Formula (Hill Notation):
C22H27ClN6O
CAS Number:
Molecular Weight:
426.94
MDL number:
UNSPSC Code:
41121800
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

Biochem/physiol Actions

LY2828360 is a potent and selective slowly acting G protein-biased CB2 cannabinoid agonist that inhibits cAMP accumulation and activates ERK1/2 signaling while failing to recruit arrestin. LY2828360 suppress chemotherapy-induced neuropathic pain created by paclitaxel without producing tolerance in mice.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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