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Merck
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Key Documents

Safety Information

SML3411

Sigma-Aldrich

LY2828360

≥98% (HPLC)

Synonym(s):

8-(2-Chlorophenyl)-2-methyl-6-(4-methyl-1-piperazinyl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine, LY 2828360

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1 KIT
CN¥6,180.57

CN¥6,180.57

Available to ship onApril 23, 2025Details

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1 KIT
CN¥6,180.57

About This Item

Empirical Formula (Hill Notation):
C22H27ClN6O
CAS Number:
1231220-79-3
Molecular Weight:
426.94
MDL number:
MFCD28010855
UNSPSC Code:
41121800
NACRES:
NA.77

CN¥6,180.57

Available to ship onApril 23, 2025Details

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

Clc1c(cccc1)c2[n](c4nc(nc(c4n2)N5CCN(CC5)C)C)C3CCOCC3

InChI

1S/C22H27ClN6O/c1-15-24-21(28-11-9-27(2)10-12-28)19-22(25-15)29(16-7-13-30-14-8-16)20(26-19)17-5-3-4-6-18(17)23/h3-6,16H,7-14H2,1-2H3

InChI key

UCMNDPDJRSEZPL-UHFFFAOYSA-N

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storage temp.

−70°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

Biochem/physiol Actions

LY2828360 is a potent and selective slowly acting G protein-biased CB2 cannabinoid agonist that inhibits cAMP accumulation and activates ERK1/2 signaling while failing to recruit arrestin. LY2828360 suppress chemotherapy-induced neuropathic pain created by paclitaxel without producing tolerance in mice.
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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000190889
    0000190888
    0000187071
    0000190889
    0000190888

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