Skip to Content
Merck
CN
All Photos(1)

Documents

SML3402

Sigma-Aldrich

HSip-1 trifluoroacetate hydrate

≥98% (HPLC)

Synonym(s):

Cyclen-AF-Cu trifluoroacetate hydrate, HSip 1, HSip1, Hydrogen Sulfide imaging probe-1, [N-(3′,6′-Dihydroxy-3-oxospiro[isobenzofuran-1(3H),9′-[9H]xanthen]-5-yl)-1,4,7,10-tetraazacyclododecane-1-acetamide-κN1,κN4,κN7,κN10]-copper(2+) trifluoroacetate hydrate

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C30H33CuN5O6 · xC2HF3O2 · yH2O
Molecular Weight:
623.16 (anhydrous free base basis)
UNSPSC Code:
41121706
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

green to black

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1OC2(C3=CC=C(NC(C[N]45CC[N@@]6([H])CC[N]7([H])CC[N@]([Cu@+2]765)([H])CC4)=O)C=C13)C8=CC=C(C=C8OC9=CC(O)=CC=C92)O.[y H2O]

Biochem/physiol Actions

HSip-1 (Cyclen-AF-Cu; Hydrogen Sulfide imaging probe-1) is a sensitive hydrogen sulfide (H2S) fluorescent probe that displays a selective turn-on fluorescence response to sulfide anion (Ex/Em = 491/516 nm), but not GSH, L-Cys, DL-Hcy, 2-ME, DTT, SCN-, Na2SO3, Na2S2O3, or sodium ascorbate. HSip-1 is not membrane-permeable and is commonly employed for detecting H2S in media/buffers, cell lysates, blood, physiological fluids and tissue homogenates. HSip-1 is commonly used in the range from 1-100 μM depending on the H2S concentrations in samples, optimal probe concentration needs to be titred.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Cytoprotective effects of hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonists are mediated by intracellular sulfane sulfur
MedChemComm, 5(10), 1577-1583 (2014)
Development of a highly selective fluorescence probe for hydrogen sulfide
Journal of the American Chemical Society, 133(45), 18003-18005 (2011)
Sulfide catabolism ameliorates hypoxic brain injury
Nature Communications, 12(1), 3108-3108 (2021)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service