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Merck
CN

SML3369

A-674563 hydrochloride

≥98% (HPLC)

Synonym(s):

αS-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-benzeneethanamine hydrochloride, (1S)-1-Benzyl-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine hydrochloride, (2S)-1-(5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine hydrochloride, A 674563 hydrochloride, A674563 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C22H22N4O · xHCl
Molecular Weight:
358.44 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD11840461

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SMILES string

[nH]1nc(c2c1ccc(c2)c3cncc(c3)OC[C@@H](N)Cc4ccccc4)C

InChI key

BPNUQXPIQBZCMR-IBGZPJMESA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

Related Categories

Biochem/physiol Actions

A-674563 is an orally available ATP-competitive pan-AKT (PKB, protein Kinase B) inhibitor (AKT1 Ki = 11 nM) with additional potency against PKA, Cdk2 GSK3β (IC50 = 1.4, 4.2,10 nM, respectively). A-674563 reduces the phosphorylation of cellular Akt substrates (0.1-10 μM; MiaPaCa-2) and enhances paclitaxel efficacy in a PC-3 xenograft model in mice in vivo (40 mg A-674563/kg via p.o. b.i.d. for 21 days, 15 mg paclitaxel/day on days 20, 24, 28).
Orally available ATP-competitive pan-AKT (PKB, protein Kinase B) inhibitor that enhances paclitaxel efficacy in a PC-3 xenograft model in mice in vivo.

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000190901
0000190900
0000175895
0000190901
0000190900

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