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About This Item
Empirical Formula (Hill Notation):
C23H24ClN3O3
CAS Number:
Molecular Weight:
425.91
UNSPSC Code:
12352200
NACRES:
NA.32
Product Name
Rasarfin, ≥98% (HPLC)
InChI key
SRZCCUYFJZQLGE-UHFFFAOYSA-N
SMILES string
O=C(C1=CC2=C(C=CC=C2)O1)NC3=CC=C(N4CCN(CC4)C(C(C)C)=O)C(Cl)=C3
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Dual Ras and ARF6 inhibitor that inhibits both receptor internalization and signaling
Rasarfin is a dual Ras and ARF6 inhibitor that inhibits both receptor internalization and signaling. It blocks agonist-mediated internalization of AT1R and other GPCRs. Rasarfin potently inhibits agonist induced ERK1/2 signaling by GPCRs, and MAPK and Akt signaling by EGFR. It prevents cancer cell proliferation.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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