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Merck
CN

SML3330

MRK-560

≥98% (HPLC)

Synonym(s):

MRK 560, MRK560, N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C19H17ClF5NO4S2
CAS Number:
677772-84-8
Molecular Weight:
517.92
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD09970622
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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SMILES string

FC(F)(F)[S](=O)(=O)N[C@@H]1CC[C@@](CC1)([S](=O)(=O)c3ccc(cc3)Cl)c2c(ccc(c2)F)F

InChI

1S/C19H17ClF5NO4S2/c20-12-1-4-15(5-2-12)31(27,28)18(16-11-13(21)3-6-17(16)22)9-7-14(8-10-18)26-32(29,30)19(23,24)25/h1-6,11,14,26H,7-10H2/t14-,18+

InChI key

WDZVWDXOIGQJIO-UJKQEGAGSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Brain-penetrant, orally active, highly potent and selective gamma-secretase inhibitor with CNS Aβ40-lowering efficacy in mice and rats in vivo.
MRK-560 is a brain-penetrant, orally active, highly potent and selective gamma-secretase inhibitor (GSI; IC50 = 0.65 nM by SH-SY5Y cellular γ-secretase substrate A4CTF breakdown assay) with little inhibitory potency against a panel of 171 enzymes/receptors. MRK-560 blocks Aβ40 & Aβ42 production with similar potency in SH-SY5Y cultures (IC50 <0.5 nM) and lowers CNS Aβ40 in rats (brain & SCF ED50 in 8h = 6 & 10 mg/kg po.) and APP-YAC mice (brain ED50 in 4h <3 mg/kg po.) in vivo

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000187781
0000187780
0000183146
0000183146
0000187781

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