All Photos(1)
Synonym(s):
(2S,4R)-1-((S)-2-(4-(4-(5-((furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Empirical Formula (Hill Notation):
C43H48N10O6S
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
SMILES string
O=C([C@H](C(C)(C)C)NC(CCCNC(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)=O)=O)N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5
Biochem/physiol Actions
UNC6852 is a potent degrader of polycomb repressive complex 2 (PRC2) that targets EED. UNC6852 selectively degrades PRC2 components EED (embryonic ectoderm development), EZH2 (enhancer of zeste homolog 2), and SUZ12 (suppressor of zeste homolog 12) via recruitment of VHL. UNC6852 exhibit anticancer activities in model systems.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Revathi Raman et al.
Scientific reports, 11(1), 15238-15238 (2021-07-29)
Tissue factor pathway inhibitor (TFPI) is an anticoagulant protein that inhibits factor VIIa and Xa in the coagulation cascade. It has been shown that forkhead box P3 protein is a TFPI transcriptional repressor. However, there are no studies on chromatin
Frances Potjewyd et al.
Cell chemical biology, 27(1), 47-56 (2019-12-14)
Protein degradation via the use of bivalent chemical degraders provides an alternative strategy to block protein function and assess the biological roles of putative drug targets. This approach capitalizes on the advantages of small-molecule inhibitors while moving beyond the restrictions
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