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Safety Information

SML3320

Sigma-Aldrich

KRA-533

≥98% (HPLC)

Synonym(s):

4-(4-(2-Bromoacetamido)butyl)benzoic acid, 4-[4-[(Bromoacetyl)amino]butyl]benzoic acid, KRAS Agonist-533, NSC 112533, NSC112533, p-[4-(2-Bromoacetamido)butyl]benzoic acid

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About This Item

Empirical Formula (Hill Notation):
C13H16BrNO3
CAS Number:
10161-87-2
Molecular Weight:
314.18
MDL number:
MFCD32194457
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(O)C1=CC=C(CCCCNC(CBr)=O)C=C1

InChI

1S/C13H16BrNO3/c14-9-12(16)15-8-2-1-3-10-4-6-11(7-5-10)13(17)18/h4-7H,1-3,8-9H2,(H,15,16)(H,17,18)

InChI key

WZQJLTLURXNPQG-UHFFFAOYSA-N

Biochem/physiol Actions

KRA-333 is a potent and selective KRAS agonist that binds directly to the GTP/GDP binding pocket of KRAS preventing the cleavage of GTP into GDP and caucusing accumulation of activated GTP-KRAS and suppression of cell growth. KRA-333 promotes apoptosis and autophagic cell death of cancer cells and inhibits growth of mutant KRAS lung cancer in xenografts mice model.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
Xu K, Park D, Magis AT, Zhang J, Zhou W, Sica GL, Ramalingam SS, Curran WJ, Deng X
Molecular Cancer, 18 (2019)

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