Skip to Content
Merck
CN

SML3281

GSK215 hydrochloride

≥98% (HPLC)

Synonym(s):

GSK 215 hydrochloride, (2S,4R)-4-hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-(4-(2-(methylcarbamoyl)phenylamino)-5-(trifluoromethyl)pyridin-2-ylamino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride, GSK-215 hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C50H59F3N10O6S · xHCl
Molecular Weight:
985.13 (free base basis)
UNSPSC Code:
51111800
NACRES:
NA.21
MDL number:
MFCD34574613

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

SMILES string

FC(F)(F)c1cnc(cc1Nc7c(cccc7)C(=O)NC)Nc2c(cc(cc2)N3CCN(CC3)CC(=O)N[C@@H](C(C)(C)C)C(=O)N4[C@@H](C[C@H](C4)O)C(=O)N[C@@H](C)c5ccc(cc5)c6[s]cnc6C)OC

InChI key

ZGSWGXNEXAXEGV-XFCHVEHOSA-N

assay

≥98% (HPLC)

form

powder

composition

, 0-8 (H2O), , 1.8-3.3 mol (HCl)

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

GSK215 is a potent and selective focal adhesion kinase (FAK) degrader (DC50 = 1.3 nM; A549 cells) composed of the FAK inhibitor VS-4718 and the VHL E3 ligase binder VHL-021. GSK215 shows cell type-dependent growth inhibition, where it inhibits A549 (IC50 <1 µM) and MCF-7 (IC50 <0.1 µM), but not BT474, in 2D cultures, while the growth of BT47 (IC50 <0.1 µM) and MCF-7 (IC50 ~0.1 µM), but not A5494, are inhibited by GSK215 in 3D cultures.
Potent and selective focal adhesion kinase (FAK) degrader composed of the FAK inhibitor VS-4718 and the VHL E3 ligase binder VHL-021.

Disclaimer

Hygroscopic

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000310069
0000310071
0000310071
0000310069
0000246998

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs
Angewandte Chemie (International Edition in English), 18;60(43), 23327-23334 (2021)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service