All Photos(1)
Synonym(s):
(3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2H-1-benzopyran-3-carboxamide, (3S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamide, (S)-Chroman 1
Empirical Formula (Hill Notation):
C24H28N4O4
CAS Number:
Molecular Weight:
436.50
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Highly potent and ROCK2-selective Rho kinase (ROCK1/2) inhibitor that is superior to Y-27632 in improving the viability of hPSCs in cultures.
Chroman 1 is a highly potent and ROCK2-selective Rho kinase inhibitor (ROCK1/2 IC50 = 52/1 pM) with much greater potency and selectivity than Y-27632 (ROCK1/2 IC50 = 71/46 nM). Chroman 1 is superior to Y-27632 in improving the viability of hPSCs in cultures (50 nM Chroman 1 is equivalent to 10 µM Y-27632; hESCs WA09 in E8 medium on vitronectin-coated plate). The combination of chroman 1, emricasan, polyamines (40 ng/ml putrescine, 4.5 ng/ml spermidine, and 8 ng/ml spermine), and trans-ISRIB (CEPT) is reported to enhance the survival of genetically stable hPSCs by simultaneously blocking several stress mechanisms that otherwise compromise cell structure and function.
Chroman 1 is a highly potent and ROCK2-selective Rho kinase inhibitor (ROCK1/2 IC50 = 52/1 pM) with much greater potency and selectivity than Y-27632 (ROCK1/2 IC50 = 71/46 nM). Chroman 1 is superior to Y-27632 in improving the viability of hPSCs in cultures (50 nM Chroman 1 is equivalent to 10 µM Y-27632; hESCs WA09 in E8 medium on vitronectin-coated plate). The combination of chroman 1, emricasan, polyamines (40 ng/ml putrescine, 4.5 ng/ml spermidine, and 8 ng/ml spermine), and trans-ISRIB (CEPT) is reported to enhance the survival of genetically stable hPSCs by simultaneously blocking several stress mechanisms that otherwise compromise cell structure and function.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Yu Chen et al.
Nature methods, 18(5), 528-541 (2021-05-05)
Human pluripotent stem cells (hPSCs) are capable of extensive self-renewal yet remain highly sensitive to environmental perturbations in vitro, posing challenges to their therapeutic use. There is an urgent need to advance strategies that ensure safe and robust long-term growth
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