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Safety Information

SML3214

Sigma-Aldrich

LDC7559

≥98% (HPLC)

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Synonym(s):
LDC 7559, N-[2-(2-Methoxyphenyl)-4H,10H-pyrazolo[5,1-c][1,4]benzoxazepin-7-yl]-acetamide
Empirical Formula (Hill Notation):
C20H19N3O3
CAS Number:
Molecular Weight:
349.38
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

Biochem/physiol Actions

LDC7559 is a potent and selective activator of PFKL (phosphofructokinase-1 liver type) that suppress excessive NOX2-dependent oxidative burst and neutrophil cell death (NETosis). LDC7559 decreases neutrophiles efficiency to kill bacteria. It prevents neutrophil-induced tissue damage.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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