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SML3197

Sigma-Aldrich

CA77.1

≥98% (HPLC)

Synonym(s):

N-(4-(6-chloroquinoxalin-2-yl)phenyl)acetamide, N-[4-(6-Chloro-2-quinoxalinyl)phenyl]-acetamide

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About This Item

Empirical Formula (Hill Notation):
C16H12ClN3O
CAS Number:
2412270-22-3
Molecular Weight:
297.74
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

Clc1cc2ncc(nc2cc1)c3ccc(cc3)NC(=O)C

InChI

1S/C16H12ClN3O/c1-10(21)19-13-5-2-11(3-6-13)16-9-18-15-8-12(17)4-7-14(15)20-16/h2-9H,1H3,(H,19,21)

InChI key

ZQXMPDVGBWOTBY-UHFFFAOYSA-N

Biochem/physiol Actions

CA77.1 is an orally available, brain penetrant, in vivo active and potent enhancer of chaperone-mediated autophagy (CMA). It improves pathology in Alzheimer′s Disease mouse models. CA77.1 activates CMA in vitro without affecting macroautophagy.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000143123
0000143124
0000139350

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