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SML3191

Sigma-Aldrich

Cotrimoxazole

≥98% (HPLC)

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Synonym(s):
4-Amino-N-(5-methyl-3-isoxazolyl)-benzenesulfonamide mixt. with 5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine, TMP/SMX, Trimethoprim/sulfamethoxazole
Empirical Formula (Hill Notation):
C14H18N4O3·5C10H11N3O3S
CAS Number:
8064-90-2
Molecular Weight:
1556.71
UNSPSC Code:
12352107
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

InChI

1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)

InChI key

WZRJTRPJURQBRM-UHFFFAOYSA-N

Biochem/physiol Actions

Cotrimoxazole is a combination antibiotic consisting of one part trimethoprim to five parts sulfamethoxazole that is used to treat a variety of bacterial infections both Gram-positive and Gram-negative. Sulfamethoxazole inhibits bacterial dihydropteroate synthase while trimethoprim inhibits bacterial dihydrofolate reductase, thereby blocking the synthesis of nucleic acids.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H361d

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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