Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

SML3186

Sigma-Aldrich

BMS-626529

≥98% (HPLC)

Synonym(s):

1-(4-Benzoyl-1-piperazinyl)-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-ethanedione, 1-(4-Benzoylpiperazin-1-yl)-2-[4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, BMS 626529, Temsavir

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C24H23N7O4
CAS Number:
701213-36-7
Molecular Weight:
473.48
MDL number:
MFCD22665723
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=C(C1=CC=CC=C1)N(CC2)CCN2C(C(C3=CNC4=C(N5C=NC(C)=N5)N=CC(OC)=C43)=O)=O

InChI

1S/C24H23N7O4/c1-15-27-14-31(28-15)22-20-19(18(35-2)13-26-22)17(12-25-20)21(32)24(34)30-10-8-29(9-11-30)23(33)16-6-4-3-5-7-16/h3-7,12-14,25H,8-11H2,1-2H3

InChI key

QRPZBKAMSFHVRW-UHFFFAOYSA-N

Biochem/physiol Actions

BMS-626529 is an HIV attachment inhibitor. HIV entry requires several steps in sequence starting with HIV surface protein gp120 binding to the CD4 receptor followed by a conformational change in gp120, eventually resulting in the fusion of HIV and the T cell membranes, allowing entry of the viral core into the cell. BMS-626529 prevents gp120 from binding to CD4. There is considerable heterogeneity within gp120 viral isolates. However, BMS-626529 was active against the majority of HIV-1 viruses with EC50 values <10 nM against most. Because of solubility problems, BMS-626529 is administered as its prodrug, BMS-663068.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service