SML3143
CIGB-300 trifluoroacetate
≥95% (HPLC)
Synonym(s):
CIGB-325 trifluoroacetate, H-GRKKRRQRRRPPQ-βA-CWMSPRHLGTC-NH2 trifluoroacetate (βA = β-alanine; C15-C25 disulfide), H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-βAla-Cys-Trp-Met-Ser-Pro-Arg-His-Leu-Gly-Thr-Cys-NH2 trifluoroacetate (Cys15-Cys25 disulfide), P15-Tat trifluoroacetate
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C127H216N54O29S3
CAS Number:
Molecular Weight:
3059.61
NACRES:
NA.77
UNSPSC Code:
12352200
Product Name
CIGB-300 trifluoroacetate, ≥95% (HPLC)
assay
≥95% (HPLC)
form
film
color
white to off-white
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
CIGB-300 (P15-Tat) is a substrate-competitive casein kinase 2 inhibitor (CK2, CKII) composed of a membrane-permeant HIV-1 Tat protein transduction domain sequence (a.a. 48-60) N-terminal to a disulfide-bridged cyclic substrate peptide that inhibits against CK2-mediated substrate HPV-16 E7 phosphorylation in vitro. CIGB-300 exhibits cytotoxic effect in various cancer cultures (IC50 from 20 to 182 μM) via apoptosis induction and effectively inhibits TC-1 tumor growth in mice in vivo (48 μmol/200 μL/mouse via daily intratumoral injection).
Substrate-competitive casein kinase 2 (CK2, CKII) inhibitor with anti-cancer efficacy in cultures and in vivo.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service