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Safety Information

SML3118

Sigma-Aldrich

Obatoclax mesylate

≥98% (HPLC)

Synonym(s):

2-(2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole, methanesulfonate salt, GX15-070 mesylate

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10 MG
CN¥1,003.17
50 MG
CN¥3,245.65

CN¥1,003.17


Estimated to ship onMarch 27, 2025Details


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10 MG
CN¥1,003.17
50 MG
CN¥3,245.65

About This Item

Empirical Formula (Hill Notation):
C20H19N3O · CH4O3S
CAS Number:
Molecular Weight:
413.49
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

CN¥1,003.17


Estimated to ship onMarch 27, 2025Details


Request a Bulk Order

Quality Level

Assay

≥98% (HPLC)

form

powder

color

dark green to black

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O=S(O)(C)=O.CC1=C(NC(C)=C1)/C=C2N=C(C3=CC4=C(N3)C=CC=C4)C=C\2OC

InChI

1S/C20H19N3O.CH4O3S/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17;1-5(2,3)4/h4-11,21-22H,1-3H3;1H3,(H,2,3,4)/b19-10-;

InChI key

ZFKXDVMHNXPEIY-PEZBNFGJSA-N

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Show Differences

1 of 4

This Item
SML3210SML1504SML2397
Dooku1 ≥98% (HPLC)

SML2397

Dooku1

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

dark green to black

color

faint brown to dark red

color

white to beige

color

white to beige

Biochem/physiol Actions

BH3 domain-targeting inhibitor against Bcl-2 family anti-apoptotic proteins with anti-cancer efficacy in vitro and in vivo.
Obatoclax (GX15–070) is a BH3 domain-targeting inhibitor against Bcl-2 family anti-apoptotic proteins, including A1/Bfl-1, Bcl-2, Bcl-B, Bcl-w, Bcl-XL, and MCL-1. Obatoclax induces cancer cell apoptosis in cultures (0.05-2 μM) and in vivo (1.25-10 mg/kg via im. ip. or iv. in mice) by overcoming Bcl-2 members-mediated resistance to BAX- or BAK-dependent apoptosis.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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