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SML3108

Sigma-Aldrich

Voclosporin

≥95% (HPLC)

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Synonym(s):
6-[(2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic acid]cyclosporin A, Cyclosporin A, 6-[(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic acid]-, ISATX247, LX 214, R 1524
Empirical Formula (Hill Notation):
C63H111N11O12
CAS Number:
515814-01-4
Molecular Weight:
1214.62
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

film or powder

color

white to off-white

storage temp.

−20°C

InChI

1S/C63H111N11O12/c1-25-27-28-29-41(15)53(76)52-57(80)66-44(26-2)59(82)68(18)34-49(75)69(19)45(30-35(3)4)56(79)67-50(39(11)12)62(85)70(20)46(31-36(5)6)55(78)64-42(16)54(77)65-43(17)58(81)71(21)47(32-37(7)8)60(83)72(22)48(33-38(9)10)61(84)73(23)51(40(13)14)63(86)74(52)24/h25,27-28,35-48,50-53,76H,1,26,29-34H2,2-24H3,(H,64,78)(H,65,77)(H,66,80)(H,67,79)/b28-27+/t41-,42+,43-,44+,45+,46+,47+,48+,50+,51+,52+,53-/m1/s1

InChI key

BICRTLVBTLFLRD-PTWUADNWSA-N

Biochem/physiol Actions

Voclosporin is a semi-synthetic calcineurin (CN) inhibitor that exhibits potent immunosuppressive activity.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H350,H361d

Hazard Classifications

Carc. 1B - Repr. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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