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Safety Information

SML3091

Sigma-Aldrich

Irresistin-16

≥98% (HPLC)

Synonym(s):

7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine,7-([1,1?-biphenyl]-4-ylmethyl), IRS-16

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About This Item

Empirical Formula (Hill Notation):
C23H19N5
CAS Number:
2624247-60-3
Molecular Weight:
365.43
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC1=NC(N)=NC2=C1C3=C(C=C2)N(CC4=CC=C(C=C4)C5=CC=CC=C5)C=C3

InChI

1S/C23H19N5/c24-22-21-18-12-13-28(20(18)11-10-19(21)26-23(25)27-22)14-15-6-8-17(9-7-15)16-4-2-1-3-5-16/h1-13H,14H2,(H4,24,25,26,27)

InChI key

CKQXMSDRDDHCOR-UHFFFAOYSA-N

Biochem/physiol Actions

Irresistin-16, an SCH 79797 derivative, is a broad spectrum bactericidal antibiotic that is effective in both gram-positive and gram-negative bacteria and exhibits low frequency of resistance. Irresistin-16 act through interruption of bacterial folate metabolism and bacterial membrane integrity. It inhibits E. coli dihydrofolate reductase FolA. Irresistin-16 is effective in mouse gonorrhea infection model.
broad spectrum bactericidal antibiotic that is effective in both gram-positive and gram-negative bacteria

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000140248
0000140247
0000132286

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James K Martin et al.
Cell, 181(7), 1518-1532 (2020-06-05)
The rise of antibiotic resistance and declining discovery of new antibiotics has created a global health crisis. Of particular concern, no new antibiotic classes have been approved for treating Gram-negative pathogens in decades. Here, we characterize a compound, SCH-79797, that

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