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SML3086

Sigma-Aldrich

Diclofenac

≥98% (HPLC)

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Synonym(s):
2-(2,6-dichloranilino) phenylacetic acid, 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid
Empirical Formula (Hill Notation):
C14H11Cl2NO2
CAS Number:
15307-86-5
Molecular Weight:
296.15
MDL number:
MFCD00056694
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=CC=CC(Cl)=C1NC2=CC=CC=C2CC(O)=O

InChI

1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)

InChI key

DCOPUUMXTXDBNB-UHFFFAOYSA-N

Biochem/physiol Actions

Diclofenac is an orally available, potent and selective nonsteroidal anti-inflammatory drug (NSAID). Diclofenac is used to treat pain and inflammatory diseases. It inhibits both cycloxygenase-1 (COX-1) and cycloxygenase-2 (COX-2).

Signal Word

Danger

Hazard Statements

H301,H361d,H372,H411

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1 Oral

Target Organs

Gastrointestinal tract

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Tomohiro Yoshida et al.
Bioorganic & medicinal chemistry, 20(19), 5705-5719 (2012-09-11)
Dipeptidyl peptidase IV (DPP-4) inhibition is suitable mechanism for once daily oral dosing regimen because of its low risk of hypoglycemia. We explored linked bicyclic heteroarylpiperazines substituted at the γ-position of the proline structure in the course of the investigation

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