All Photos(1)
Synonym(s):
2-[[Hydroxy(tetradecyloxy)phosphinyl]oxy]-N,N,N-trimethyl- ethanaminium inner salt, CDI 166493, D 19390, FOS 14, Fos-choline 14, Tetradecylphosphocholine, n-Tetradecyl-phosphocholine, n-Tetradecylphosphocholine
Empirical Formula (Hill Notation):
C19H42NO4P
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
[O-]P(OCCCCCCCCCCCCCC)(OCC[N+](C)(C)C)=O
InChI
1S/C19H42NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-18-23-25(21,22)24-19-17-20(2,3)4/h5-19H2,1-4H3
InChI key
BETUMLXGYDBOLV-UHFFFAOYSA-N
Biochem/physiol Actions
n-Tetradecylphosphocholine (C14PC), a more stable analog of myristoyl lysophosphatidylcholine, is an inhibitor of MARSA virulence. C14PC is a broad-spectrum inhibitor of Panton–Valentine leucocidin (PVL), LukED and α−toxin. C14PC protects primary human immune cells in vitro against cytolysis by PVL and α-toxin. C14PC can be used as a detergent for membrane solubilization.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Jie Liu et al.
The Journal of biological chemistry, 295(18), 5944-5959 (2020-03-18)
The rapid emergence and dissemination of methicillin-resistant Staphylococcus aureus (MRSA) strains poses a major threat to public health. MRSA possesses an arsenal of secreted host-damaging virulence factors that mediate pathogenicity and blunt immune defenses. Panton-Valentine leukocidin (PVL) and α-toxin are
Danyang Guo et al.
Metabolism: clinical and experimental, 107, 154232-154232 (2020-04-18)
Parasympathetic nerve (PN) signaling plays a crucial role in the maintenance of pancreatic β-cell volume density (Vβ). PN may be pathologically affected in diabetic polyneuropathy (DPN). However, the association between the reduction of PNs in islets and Vβ and the
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