Skip to Content
Merck
CN
All Photos(1)

Documents

SML3072

Sigma-Aldrich

8-pCPT-2′-O-Me-cAMP-AM

≥98% (HPLC)

Synonym(s):

8-pCPT-2′-O-Me-cAMP-AM, 007-AM, 8-(4-Chlorophenylthio)-2′-O-methyladenosine-3′,5′-cyclic monophosphate, acetoxymethyl ester, 8-CPT-2′-O-Me-cAMP-AM, 8-CPT-AM, 8-pCPT-AM, CPT-AM

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C20H21ClN5O8PS
CAS Number:
1152197-23-3
Molecular Weight:
557.90
MDL number:
MFCD26792583
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

film or powder

color

colorless to light yellow

storage temp.

−20°C

SMILES string

NC1=NC=NC2=C1N=C(N2[C@H](O[C@H](CO3)[C@H]4OP3(OCOC(C)=O)=O)[C@@H]4OC)SC5=CC=C(C=C5)Cl

InChI

1S/C20H21ClN5O8PS/c1-10(27)30-9-32-35(28)31-7-13-15(34-35)16(29-2)19(33-13)26-18-14(17(22)23-8-24-18)25-20(26)36-12-5-3-11(21)4-6-12/h3-6,8,13,15-16,19H,7,9H2,1-2H3,(H2,22,23,24)/t13-,15-,16-,19-,35?/m1/s1

InChI key

FZMWUFYPEVDWPA-SILPBKOMSA-N

Biochem/physiol Actions

8-pCPT-2′-O-Me-cAMP-AM (CPT-AM) is a membrane-permeant acetoxymethyl (AM) ester precusor form of the EPAC-selective cAMP analog (ESCA) 8-pCPT-2′-O-Me-cAMP (CPT). CPT-AM is >100-times more cell-permeable than CPT (by FRET using CFP-Epac-YFP-expressing A431; No effect by PKA FRET assay) and >100-times more efficient in stimulating cellular Rap1 activation (ECmax = 0.1 μM/CPT-AM vs. 100 μM/CPT; HUVECs).

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service