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Merck
CN

SML3045

XL177B

≥98% (HPLC)

Synonym(s):

(R)-N-(4-benzyl-5-(4-hydroxy-4-((7-(3-(4-methylpiperazin-1-yl)propanamido)-4-oxoquinazolin-3(4H)-yl)methyl)piperidin-1-yl)-5-oxopentyl)-9-chloro-5,6,7,8-tetrahydroacridine-3-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C48H57ClN8O5
CAS Number:
2417089-75-7
Molecular Weight:
861.47
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

XL177B, ≥98% (HPLC)

InChI key

UYJWYMWIVMCGQZ-PGUFJCEWSA-N

SMILES string

O=C1N(CC2(O)CCN(C([C@@H](CC3=CC=CC=C3)CCCNC(C4=CC(N=C(CCCC5)C5=C6Cl)=C6C=C4)=O)=O)CC2)C=NC7=CC(NC(CCN8CCN(C)CC8)=O)=CC=C71

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

XL177B is a negative enantiomeric control for a cell penetrant, potent and highly selective covalent inhibitor of the deubiquitinating enzyme USP7 XL177A.
negative enantiomeric control for a cell penetrant, potent and highly selective covalent inhibitor of the USP7 XL177A

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000130293
0000130292
0000127148

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Nathan J Schauer et al.
Scientific reports, 10(1), 5324-5324 (2020-03-27)
Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) that removes ubiquitin tags from specific protein substrates in order to alter their degradation rate and sub-cellular localization. USP7 has been proposed as a therapeutic target in several cancers because
Jonathan W Bushman et al.
Cell chemical biology, 28(1), 78-87 (2020-10-03)
Deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin, thereby reversing the activity of E3 ubiquitin ligases and are central to the control of protein abundance and function. Despite the growing interest in DUBs as therapeutic targets, cellular functions for DUBs

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