All Photos(1)
Synonym(s):
(2R)-N-[[3-Chloro-5-(trifluoromethyl)-2-pyridyl]methyl]-2-cyclopropyl-1-(4-fluorophenyl)sulfonyl-1′,1′-dioxo-spiro[indoline-3,4′-thiane]-5-carboxamide, (2R)-N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2,3,5,6-hexahydro-spiro[3H-indole-3,4-[4H]thiopyran]-5-carboxamide 1,1-dioxide
Empirical Formula (Hill Notation):
C29H26ClF4N3O5S2
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
optical activity
[α]/D 105 to 125°, c = 0.5 in chloroform-d
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1=CC2=C(N(S(=O)(C3=CC=C(F)C=C3)=O)[C@H](C4CC4)C2(CC5)CCS5(=O)=O)C=C1)NCC6=NC=C(C(F)(F)F)C=C6Cl
Biochem/physiol Actions
BAY-786 is a negative control for an orally available, non-toxic, potent, and selective GnRH-R antagonist BAY-784.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
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Olaf Panknin et al.
Journal of medicinal chemistry, 63(20), 11854-11881 (2020-09-23)
The growth of uterine fibroids is sex hormone-dependent and commonly associated with highly incapacitating symptoms. Most treatment options consist of the control of these hormonal effects, ultimately blocking proliferative estrogen signaling (i.e., oral contraceptives/antagonization of human gonadotropin-releasing hormone receptor [hGnRH-R]
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