All Photos(1)
Synonym(s):
6-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dien-1-yl)-2-methylimidazo[1,2-a]pyrazin-3(7H)-one, 6-[4-[4-(Dimethylamino)phenyl]-1,3-butadien-1-yl]-2-methyl-imidazo[1,2-a]pyrazin-3(7H)-one
Empirical Formula (Hill Notation):
C19H20N4O
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
faint yellow to dark orange
solubility
H2O: 0.1 mg/mL (warmed)
storage temp.
2-8°C
SMILES string
CN(C1=CC=C(C=C1)/C=C/C=C/C2=CN3C(N=C(C3=O)C)=CN2)C
Biochem/physiol Actions
ADLumin-1 brain blood barrier penetrant smart chemiluminescence probe for Aβ (amyloid beta) species. Upon binding to Aβ, ADLumin-1 chemiluminescence dramatically increases and its peak shifts from 590 nm to 540 nm. ADLumin-1 is suitable for in vivo dually-amplify signal via chemiluminescence resonance energy transfer (DAS-CRET) with CRANAD-3 a smart NIRF (near infrared fluorescence imaging) probe for Aβs. Apparently both probes bind to Aβ aggregates in close proximity.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
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Jing Yang et al.
Nature communications, 11(1), 4052-4052 (2020-08-15)
Turn-on fluorescence imaging is routinely studied; however, turn-on chemiluminescence has been rarely explored for in vivo imaging. Herein, we report the design and validation of chemiluminescence probe ADLumin-1 as a turn-on probe for amyloid beta (Aβ) species. Two-photon imaging indicates
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