All Photos(1)
Synonym(s):
5-Amino-1H-v-triazolo[d]pyrimidin-7-ol, 5-Amino-3,6-dihydro-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one, 5-Amino-7-hydroxy-1H-v-triazolo[d]pyrimidine, 8-AG, Guanazolo, NSC 151069, NSC 223526, pathocidin, 2-Amino-6-hydroxy-8-azapurine, 2-Amino-6-oxy-8-azapurine
Empirical Formula (Hill Notation):
C4H4N6O
CAS Number:
Molecular Weight:
152.11
Beilstein:
171098
MDL number:
UNSPSC Code:
12352200
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
mp
>300 °C (lit.)
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
NC1=Nc2[nH]nnc2C(=O)N1
InChI
1S/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h(H4,5,6,7,8,9,10,11)
InChI key
LPXQRXLUHJKZIE-UHFFFAOYSA-N
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Biochem/physiol Actions
8-Azaguanine is a triazole-antimetabolite that displays varies pharmacological effects including anticancer, antiviral and antifungal. It is easily incorporated into ribonucleic acids including rRNA and tRNA. 8-Azaguanine appears to alter mRNA splicing in SF3B1 mutant cells. 8-Azaguanine novel immunomodulatory drug (IMiD) that significantly increases the cytotoxicity of NK cells.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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