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Key Documents

Safety Information

SML2948

Sigma-Aldrich

Mca-APK(Dnp)-OH trifluoroacetate

≥97% (HPLC)

Synonym(s):

Mca-APK(Dnp) TFA salt (Mca = 7-Methoxycoumarin-4-yl; Dnp = 2,4-dinitrophenyl), Mca-Ala-Pro-Lys(Dnp) TFA salt, Mca-Ala-Pro-Lys(Dnp)-OH TFA salt

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48 EA
CN¥1,754.36

CN¥1,754.36

Estimated to ship onApril 28, 2025Details

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48 EA
CN¥1,754.36

About This Item

Empirical Formula (Hill Notation):
C32H36N6O12 · xC2HF3O2
Molecular Weight:
696.66 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

CN¥1,754.36

Estimated to ship onApril 28, 2025Details

Request a Bulk Order

Quality Level

100

Assay

≥97% (HPLC)

form

film or powder

storage condition

desiccated

color

white to dark beige

storage temp.

−20°C

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pore size

0.22 μm

pore size

0.45 μm

pore size

0.45 μm

pore size

0.22 μm

manufacturer/tradename

Corning 8169

manufacturer/tradename

Corning 8170

manufacturer/tradename

Corning 8163

manufacturer/tradename

Corning 8160

material

Nylon membrane, polypropylene housing, natural polypropylene cap, polypropylene tube

material

Nylon membrane, natural polypropylene cap, polypropylene housing, polypropylene tube

material

cellulose acetate membrane, natural polypropylene cap, polypropylene housing, polypropylene tube

material

cellulose acetate membrane, natural polypropylene cap, polypropylene housing, polypropylene tube

working volume

500 μL

working volume

500 μL

working volume

500 μL

working volume

500 μL

packaging

case of 200 units (two packs of 100 each)

packaging

case of 200 units (two packs of 100 each)

packaging

case of 100 unit

packaging

case of 96 units

Biochem/physiol Actions

Mca-APK(Dnp)-OH is a widely used fluorescent substrate for angiotensin-converting enzyme 2 (ACE2 cleaves between P & K). Proteolytic cleavage separates 7-methoxycoumarin-4-acetyl (Mca) from the fluorescence-quenching group 2,4-dinitrophenyl (Dnp), resulting in increased Mca fluorescence (Ex: 320-328 nm, Em: 405-420 nm). The fluorescence increase over background upon Mca-APK(Dnp) cleavage is more than 14-fold higher than that of Mca-YVADAPK(Dnp), while only Mca-YVADAPK(Dnp), but not Mca-APK(Dnp), can also be used for assessing caspase-1 (ICE) activity.
Popular fluorescent substrate for angiotensin-converting enzyme 2 (ACE2).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
0000427659
0000427662
0000427662
0000427659
0000340825

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Chintan K Gandhi et al.
Lung, 197(2), 227-233 (2019-02-14)
Pancreatic digestive enzymes present in meconium might be responsible for meconium-induced lung injury. The local Renin Angiotensin System plays an important role in lung injury and inflammation. Particularly, angiotensin converting enzyme-2 (ACE-2) has been identified as a protective lung enzyme against
Danielle Stoll et al.
Physiological reports, 7(11), e14105-e14105 (2019-06-06)
The kidney is an important target of the renin-ANG-aldosterone system (RAAS). To date, several studies have demonstrated the existence of a local RAAS in various tissues, including the renal tissue. The mineralocorticoid aldosterone is known to play a critical role
Xiaomiao Zhang et al.
Archives of biochemistry and biophysics, 672, 108061-108061 (2019-07-30)
Autophagy exerts a dual role in promoting cell death or survival. Recent studies have shown that it may play an important role in lipopolysaccharide (LPS)-induced acute lung injury (ALI). It was also suggested that angiotensin converting enzyme 2 (ACE2) may
A P O Leite et al.
Journal of cellular physiology, 234(12), 22809-22818 (2019-05-28)
Diabetes mellitus and its complications have become a major health concern in Western countries. Increased activity of the intrarenal renin-angiotensin system (RAS) contributes to diabetic nephropathy (DN). We previously reported that in mesangial cells, the high glucose concentration (HG) leads
Charles E Evans et al.
Acta neuropathologica, 139(3), 485-502 (2020-01-27)
Mid-life hypertension and cerebrovascular dysfunction are associated with increased risk of later life dementia, including Alzheimer's disease (AD). The classical renin-angiotensin system (cRAS), a physiological regulator of blood pressure, functions independently within the brain and is overactive in AD. cRAS-targeting
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