All Photos(1)
Synonym(s):
5-((5-Chloro-2-methoxyphenyl)sulfonamido)nicotinamide, 5-[[(5-Chloro-2-methoxyphenyl)sulfonyl]amino]-3-pyridinecarboxamide
Empirical Formula (Hill Notation):
C13H12ClN3O4S
CAS Number:
Molecular Weight:
341.77
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
SBI-425 is an orally available, potent and selective inhibitor of TNAP (tissue-nonspecific alkaline phosphase).
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Campbell R Sheen et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(5), 824-836 (2014-11-28)
Medial vascular calcification (MVC) is a pathological phenomenon that causes vascular stiffening and can lead to heart failure; it is common to a variety of conditions, including aging, chronic kidney disease, diabetes, obesity, and a variety of rare genetic diseases.
Anthony B Pinkerton et al.
Bioorganic & medicinal chemistry letters, 28(1), 31-34 (2017-11-28)
Tissue-nonspecific alkaline phosphatase (TNAP) is an ectoenzyme crucial for bone matrix mineralization via its ability to hydrolyze extracellular inorganic pyrophosphate (ePPi), a potent mineralization inhibitor, to phosphate (Pi). By the controlled hydrolysis of ePPi, TNAP maintains the correct ratio of
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