SML2876
DLCI-1
≥98% (HPLC)
Synonym(s):
5-(4-Ethyl-3-pyridinyl)-2-thiophenemethanamine, 5-(4-ethylpyridin-3-yl)thiophe-2-yl)methanamine
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About This Item
Empirical Formula (Hill Notation):
C12H14N2S
CAS Number:
Molecular Weight:
218.32
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
oil
color
colorless to yellow
storage temp.
2-8°C
SMILES string
[s]1c(ccc1c2cnccc2CC)CN
InChI key
PMFPLVYHUVJODG-UHFFFAOYSA-N
Biochem/physiol Actions
DLCI-1 is an orally available potent and selective inhibitor of cytochrome P450 2A6 (CYP2A6) that significantly decreases nicotine self-administration in both male and female mice.
orally available potent and selective inhibitor of CYP2A6 that significantly decreases nicotine self-administration mice
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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Yen-Chu Chen et al.
The Journal of pharmacology and experimental therapeutics, 372(1), 21-29 (2019-10-20)
During tobacco and e-cigarette use, nicotine is mainly metabolized in the human liver by cytochrome P450 2A6 (CYP2A6). Given that a slower CYP2A6 metabolism has been associated with less vulnerability to develop nicotine dependence, the current studies sought to validate
Travis T Denton et al.
Journal of medicinal chemistry, 61(16), 7065-7086 (2018-07-12)
Cigarette smoking causes nearly one in every five deaths in the United States. The development of a specific inhibitor of cytochrome P450 2A6 (CYP2A6), the major nicotine-metabolizing enzyme in humans, which could be prescribed for the cessation of cigarette smoking
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