All Photos(1)
Synonym(s):
(1R,4R,5R)-rel-4-(4-Hydroxyphenyl)-6-methyl-3-oxabicyclo[3.3.1]non-6-ene-1-methanol, (1R,4R,5R)-rel-l-4-(5-(Hydroxymethyl)-8-methyl-3-oxabicyclo[3.3.1]non-7-en-2-yl))-phenol
Empirical Formula (Hill Notation):
C16H20O3
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Biochem/physiol Actions
AB-1 is a highly selective estrogen receptors ERα and ERβ modulator over G protein-coupled estrogen receptor GPER. AB-1 is an agonist of ER transcriptional activity, but it acts as an antagonist of rapid signaling through ERα.
highly selective estrogen receptors ERα and ERβ modulator over G protein-coupled estrogen receptor GPER
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Robert W Hsieh et al.
The Journal of biological chemistry, 281(26), 17909-17919 (2006-05-02)
Estrogen receptors alpha (ERalpha) and beta (ERbeta) have distinct functions and differential expression in certain tissues. These differences have stimulated the search for subtype-selective ligands. Therapeutically, such ligands offer the potential to target specific tissues or pathways regulated by one
Chetana M Revankar et al.
Cell chemical biology, 26(12), 1692-1702 (2019-11-11)
Estrogen exerts extensive and diverse effects throughout the body of women. In addition to the classical nuclear estrogen receptors (ERα and ERβ), the G protein-coupled estrogen receptor GPER is an important mediator of estrogen action. Existing ER-targeted therapeutic agents act
Lawrence G Hamann et al.
Bioorganic & medicinal chemistry letters, 15(5), 1463-1466 (2005-02-17)
An oxabicyclic template for estrogen receptor alpha and beta agonists has been identified which can be tuned to provide moderate levels of selectivity for either receptor sub-type. Structure-activity relationships within this phenol-substituted oxabicyclo[3.3.1]nonene series are described. Select compounds from the
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