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Merck
CN

SML2849

Taltirelin

≥98% (HPLC)

Synonym(s):

(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-L-prolinamide, (S)-N-((S)-1-((S)-2-Carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-1-methyl-2,6-dioxohexahydropyrimidine-4-carboxamide, (S)-N-[(Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-L-histidyl-L-prolinamide, TA 0910, TA-0910, TA0910

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About This Item

Empirical Formula (Hill Notation):
C17H23N7O5 · xC2H4O2
CAS Number:
103300-74-9
Molecular Weight:
405.41 (free base basis)
UNSPSC Code:
12352107

Key Documents

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assay

≥98% (HPLC)

form

powder

color

white to off-white

storage temp.

−20°C

Biochem/physiol Actions

Taltirelin (TA-0910) is a thyrotropin-releasing hormone (TRH) mimetic with greatly enhanced brain-penetration, oral activity and stability. Taltirelin shortens the duration of pentobarbital-induced sleep (0.3-3 mg/kg po. or 0.03-0.3 mg/kg iv.), antagonizes reserpine-induced hypothermia (1 or 3 mg/kg po. or 0.1-0.3 mg/kg ip.), and enhances the spontaneous motor activity (30 mg/kg po.) in mice in vivo, while TRH produces these effects at about 100 times higher doses.
Thyrotropin-releasing hormone (TRH) mimetic with greatly enhanced brain-penetration, oral activity, stability and in vivo efficacy than TRH

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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