SML2736
NPBA
≥98% (HPLC)
Synonym(s):
N-(2-((4-nitro-2-(trifluoromethyl)phenyl)amino)ethyl)benzamide
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About This Item
Empirical Formula (Hill Notation):
C16H14F3N3O3
CAS Number:
Molecular Weight:
353.30
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
FC(F)(F)c1c(ccc(c1)[N+](=O)[O-])NCCNC(=O)c2ccccc2
InChI key
LUJDPMMSYZQCHA-UHFFFAOYSA-N
Biochem/physiol Actions
NPBA is a potent and selective agonist (activator) of potassium K2P channel TASK-3 (KCNK9).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Fuyun Tian et al.
Molecular pharmacology, 96(1), 26-35 (2019-04-25)
The TASK-3 channel is a member of the K2P family that is important for the maintenance of the resting membrane potential. Previous studies have demonstrated that the TASK-3 channel is involved in several physiologic and pathologic processes, including sleep/wake control
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