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Merck
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Key Documents

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Safety Information

SML2733

Sigma-Aldrich

RLA8

≥98% (HPLC)

Synonym(s):

8-[3-Methoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]phenoxy]octanoic acid

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5 MG
CN¥558.80
25 MG
CN¥2,260.64

CN¥558.80

Estimated to ship onMay 19, 2025Details

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5 MG
CN¥558.80
25 MG
CN¥2,260.64

About This Item

Empirical Formula (Hill Notation):
C24H30O5
CAS Number:
1891020-45-3
Molecular Weight:
398.49
UNSPSC Code:
12352200
NACRES:
NA.77

CN¥558.80

Estimated to ship onMay 19, 2025Details

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O(CCCCCCCC(=O)O)c1cc(cc(c1)\C=C\c2ccc(cc2)OC)OC

InChI

1S/C24H30O5/c1-27-21-13-11-19(12-14-21)9-10-20-16-22(28-2)18-23(17-20)29-15-7-5-3-4-6-8-24(25)26/h9-14,16-18H,3-8,15H2,1-2H3,(H,25,26)/b10-9+

InChI key

MNKZDYGBWDHRMX-MDZDMXLPSA-N

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Show Differences

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This Item
P0022SML0364SML0393
RLA8 ≥98% (HPLC)

SML2733

RLA8

PS48 ≥98% (HPLC)

P0022

PS48

RAD51 Inhibitor B02 ≥98% (HPLC)

SML0364

RAD51 Inhibitor B02

QNZ46 ≥98% (HPLC)

SML0393

QNZ46

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: >20 mg/mL

solubility

DMSO: ≥5 mg/mL

solubility

DMSO: 5 mg/mL (warmed; clear solution)

storage condition

protect from light

storage condition

protect from light

storage condition

-

storage condition

-

Biochem/physiol Actions

RLA8 is an orally available and potent agonist of peroxisome proliferator-activated receptors (PPARs)-α/γ/δ and G-protein-coupled receptor 40 (GPR40). RLA8 reverses the proregression of pathological changes such as hepatic lipid accumulation, steatosis, inflammation and fibrosis in mice models of nonalcoholic steatohepatitis (NASH). Also, it improves serum HDL cholesterol, reduce hepatic free fatty acid and triglyceride levels, and alleviate insulin resistance.
orally available and potent agonist for PPARs-α/γ/δ and GPR40 that exhibits efficacy to reverse nonalcoholic steatohepatitis and fibrosis

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000097136
    0000097137
    0000094542

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    Meng Hua Li et al.
    The Journal of pharmacology and experimental therapeutics, 369(1), 67-77 (2019-02-13)
    Nonalcoholic fatty liver disease (NAFLD) is a very common chronic hepatic disease, with nonalcoholic steatohepatitis (NASH) as a major and severe subcategory that can lead to cirrhosis and hepatocellular carcinoma, and thereby to a high mortality rate. Currently, there has

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