All Photos(1)
Synonym(s):
(S)-1-(2-((6-fluorobenzo[d]thiazol-2-yl)amino)-3-phenylpropyl)-1′H-spiro[piperidine-4,4′-quinazolin]-2′(3′H)-one, 1-[(2S)-2-[(6-fluoro-2-benzothiazolyl)amino]-3-phenylpropyl]-spiro[piperidine-4,4′(1′H)-quinazolin]-2′(3′H)-one
Empirical Formula (Hill Notation):
C28H28FN5OS
CAS Number:
Molecular Weight:
501.62
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
NVS-ZP7-4 is a potent inhibitor of the Notch signaling pathway that induces endoplasmic reticulum (ER) stress and induces apoptosis in T-ALL cell lines. NVS-ZP7-4 is a potent and selective inhibitor of SLC39A7 (ZIP7) zinc transporter that increases ER zinc levels.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Erin Nolin et al.
Nature chemical biology, 15(2), 179-188 (2019-01-16)
The identification of activating mutations in NOTCH1 in 50% of T cell acute lymphoblastic leukemia has generated interest in elucidating how these mutations contribute to oncogenic transformation and in targeting the pathway. A phenotypic screen identified compounds that interfere with
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