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Safety Information

SML2722

Sigma-Aldrich

MU140

≥98% (HPLC)

Synonym(s):

1-Methyl-4-(9-(2-phenyl-phenyl)-7-oxa-2-aza-bicyclo[4.3.0]nona-1,3,5,8-tetraen-3-yl)-1H-pyrazole, 3-(Biphenyl-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)furo[3,2-b]pyridine, 3-[1,1′-Biphenyl]-2-yl-5-(1-methyl-1H-pyrazol-4-yl)-furo[3,2-b]pyridine, MU1210 inactive control, MU1210 negative control, VN270, VN339 inactive control, VN339 negative control

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About This Item

Empirical Formula (Hill Notation):
C23H17N3O
CAS Number:
1821205-76-8
Molecular Weight:
351.40
UNSPSC Code:
41121813
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

CN(N=C1)C=C1C2=CC=C(OC=C3C4=C(C5=CC=CC=C5)C=CC=C4)C3=N2

InChI key

QSBNKGGRYOLZND-UHFFFAOYSA-N

Biochem/physiol Actions

MU140 is a structure analog of and the recommended inactive (negative) control for MU1210, an inhibitor against cdc-like kinase (cdc2-like kinase) CLK1, CLK2, CLK4, and homeodomain-interacting protein kinase 2 (HIPK2). MU140 exhibits no inhbitory potency toward CLK1/2/3/4, DYRK1a/1b/2 or HIPK1/2/3 (IC50 >3 μM).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000100159
0000100160
0000094689

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Václav Němec et al.
Angewandte Chemie (International ed. in English), 58(4), 1062-1066 (2018-12-21)
Reported is the identification of the furo[3,2-b]pyridine core as a novel scaffold for potent and highly selective inhibitors of cdc-like kinases (CLKs) and efficient modulators of the Hedgehog signaling pathway. Initially, a diverse target compound set was prepared by synthetic

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