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Merck
CN

SML2704

BAY-294

≥98% (HPLC)

Synonym(s):

BAY-294, 6,7-Dimethoxy-2-methyl-N-[(S)-1-(4-{2-[(methylamino)methyl]phenyl}thien-2-yl)ethyl]quinazolin-4-amine, BAY 293 (S)-enantiomer, BAY 293 control, BAY 294, BAY-293 (S)-enantiomer, BAY-293 control, BAY293 (S)-enantiomer, BAY293 control, BAY294

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About This Item

Empirical Formula (Hill Notation):
C25H28N4O2S
CAS Number:
2244904-69-4
Molecular Weight:
448.58
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

BAY-294, ≥98% (HPLC)

InChI

1S/C25H28N4O2S/c1-15(24-10-18(14-32-24)19-9-7-6-8-17(19)13-26-3)27-25-20-11-22(30-4)23(31-5)12-21(20)28-16(2)29-25/h6-12,14-15,26H,13H2,1-5H3,(H,27,28,29)/t15-/m0/s1

InChI key

WEGLOYDTDILXDA-HNNXBMFYSA-N

SMILES string

C[C@@H](C1=CC(C2=CC=CC=C2CNC)=CS1)NC3=C4C=C(C(OC)=CC4=NC(C)=N3)OC

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +86.0 to +106.0°, c = 1.0 in DMSO

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

BAY-294 corresponds to the (S)-enantiomer of and the recommended control for the selective SOS1-KRAS interaction inhibitor BAY-293 (IC50 = 2.34 μM/BAY-294 vs. 21 nM/BAY-293; 10 nM hSOS1cat & 5 nM hKRAS G12C). BAY-294 exhibits little potency against SOS1-mediated KRAS activation (IC50 = 3.91 μM/BAY-294 vs. 52 nM/BAY-293; 10 nM SOS1cat & 50 nM wt hKRAS).
Control (S)-enantiomer of the selective SOS1-KRAS interaction inhibitor BAY-293.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000126806
0000126805
0000118802

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