All Photos(1)
Synonym(s):
2-{2-[3-(5-nitro-2-furyl)-2-propen-1-ylidene]hydrazino}-2-oxoethylbenzene
Empirical Formula (Hill Notation):
C15H13N3O4
Molecular Weight:
299.28
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
faint yellow to dark orange
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Biochem/physiol Actions
ES24 is an Eeyarestatin 1 analog that blocks protein translocation in vitro and more effectively enhances Sec61-mediated Ca2+ leakage from Endoplasmic Reticulum (ER). Apparently ES24 keep Sec61 in open position allowing Ca2+ ions to move freely through the aqueous channel present. It causes cell-type-specific Ca2+-dependent cell death.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Igor Gamayun et al.
Cell chemical biology, 26(4), 571-583 (2019-02-26)
Eeyarestatin 1 (ES1) inhibits p97-dependent protein degradation, Sec61-dependent protein translocation into the endoplasmic reticulum (ER), and vesicular transport within the endomembrane system. Here, we show that ES1 impairs Ca2+ homeostasis by enhancing the Ca2+ leakage from mammalian ER. A comparison
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