SML2667
AC261066
≥98% (HPLC)
Synonym(s):
4-[4-(2-Butoxyethoxy)-5-methyl-2-thiazolyl]-2-fluorobenzoic acid, AC 261066, AC-261066
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C17H20FNO4S
CAS Number:
Molecular Weight:
353.41
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
Fc1c(ccc(c1)c2[s]c(c(n2)OCCOCCCC)C)C(=O)O
InChI
1S/C17H20FNO4S/c1-3-4-7-22-8-9-23-15-11(2)24-16(19-15)12-5-6-13(17(20)21)14(18)10-12/h5-6,10H,3-4,7-9H2,1-2H3,(H,20,21)
InChI key
HSAOETBFVAWNRP-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
AC261066 is an orally active, selective and potent synthetic agonist for the retinoic acid β2-receptor (RARβ2) that decreases oxidative stress in mice fed a high-fat diet. AC261066 reduce ischemia/reperfusion injury of the heart in mice models.
orally active, selective and potent synthetic agonist for the retinoic acid β2-receptor (RARβ2)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Alice Marino et al.
The Journal of pharmacology and experimental therapeutics, 366(2), 314-321 (2018-06-17)
We previously discovered that oral treatment with AC261066, a synthetic selective agonist for the retinoic acid β2-receptor, decreases oxidative stress in the liver, pancreas, and kidney of mice fed a high-fat diet (HFD). Since hyperlipidemic states are causally associated with
Steven E Trasino et al.
Journal of molecular medicine (Berlin, Germany), 94(10), 1143-1151 (2016-06-09)
Hepatic stellate cells (HSCs) are an important cellular target for the development of novel pharmacological therapies to prevent and treat nonalcoholic fatty liver diseases (NAFLD). Using a high fat diet (HFD) model of NAFLD, we sought to determine if synthetic
Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist.
Birgitte W Lund et al.
Journal of medicinal chemistry, 48(24), 7517-7519 (2005-11-24)
4'-Octyl-4-biphenylcarboxylic acid (1g, AC-55649) was identified as a highly isoform-selective agonist at the human RARbeta2 receptor in a functional intact cell-based screening assay. The subsequent hit to lead optimization transformed the lipophilic, poorly soluble hit into a more potent and
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service