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Key Documents

Safety Information

SML2650

Sigma-Aldrich

T3-CLK

≥98% (HPLC)

Synonym(s):

4-(2-Methyl-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl)-N-(6-(pyridin-4-yl)imidazo[1,2-a]pyridin-2-yl)benzamide, 4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide, T3

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1 EA
CN¥1,118.65

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1 EA
CN¥1,118.65

About This Item

Empirical Formula (Hill Notation):
C28H30N6O2
CAS Number:
Molecular Weight:
482.58
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

CN¥1,118.65


Please contact Customer Service for Availability

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Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

[n]21c(nc(c2)NC(=O)c4ccc(cc4)C(C)(C)C(=O)N5CCN(CC5)C)ccc(c1)c3ccncc3

InChI

1S/C28H30N6O2/c1-28(2,27(36)33-16-14-32(3)15-17-33)23-7-4-21(5-8-23)26(35)31-24-19-34-18-22(6-9-25(34)30-24)20-10-12-29-13-11-20/h4-13,18-19H,14-17H2,1-3H3,(H,31,35)

InChI key

IEFFSHLHNYVSEF-UHFFFAOYSA-N

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This Item
AB9076AB5882AB9074
antibody form

serum

antibody form

serum

antibody form

affinity purified immunoglobulin

antibody form

serum

species reactivity

mouse, human

species reactivity

mouse, rat, human

species reactivity

rat

species reactivity

human, mouse

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

Gene Information

dog ... Itpr1(476548)
human ... ITPR1(3708)
mouse ... Itpr1(16438)
rat ... Itpr1(25262)

Gene Information

human ... ITPR3(3710)
mouse ... Itpr3(16440)
rat ... Itpr3(25679)

Gene Information

human ... ITPR1(3708)

Gene Information

human ... ITPR2(3709)

Biochem/physiol Actions

T3-CLK (T3) is a cell permeable, highly potent and selective cell-base stable inhibitor of CDC-like kinase (CLK) that exhibits dose-dependent alternative splicing effects in HCT116 colorectal cancer cells. T3-CLK increases conjoined gene (CG) transcription.
cell permeable, highly potent and selective cell-base stable inhibitor of CDC-like kinase (CLK)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Susanne Müller et al.
eLife, 7 (2018-04-21)
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and
Tyler Funnell et al.
Nature communications, 8(1), 7-7 (2017-02-25)
CDC-like kinase phosphorylation of serine/arginine-rich proteins is central to RNA splicing reactions. Yet, the genomic network of CDC-like kinase-dependent RNA processing events remains poorly defined. Here, we explore the connectivity of genomic CDC-like kinase splicing functions by applying graduated, short-exposure

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