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Safety Information

SML2637

Sigma-Aldrich

NPD8733

≥98% (HPLC)

Synonym(s):

N-[2-(4-Methoxybenzoyl)-3-benzofuranyl]acetamide

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About This Item

Empirical Formula (Hill Notation):
C18H15NO4
CAS Number:
696655-62-6
Molecular Weight:
309.32
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N(c1c2c([o]c1C(=O)c3ccc(cc3)OC)cccc2)C(=O)C

InChI

1S/C18H15NO4/c1-11(20)19-16-14-5-3-4-6-15(14)23-18(16)17(21)12-7-9-13(22-2)10-8-12/h3-10H,1-2H3,(H,19,20)

InChI key

NQZBUYPGHZTWIR-UHFFFAOYSA-N

Biochem/physiol Actions

NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. NPD8733 binds to valosin-containing protein (VCP)/p97.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000072664
0000072665
0000070619

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Kruthi Suvarna et al.
The Journal of biological chemistry, 294(9), 2988-2996 (2019-01-06)
Carcinoma-associated fibroblasts are fibroblasts activated by surrounding cancer cells. Carcinoma-associated fibroblasts exhibit enhanced cell migration, which plays an important role in cancer metastasis. Previously, we demonstrated enhanced migration of NIH3T3 fibroblasts when they were cultured in the presence of MCF7

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