SML2611
Bobcat339
≥98% (HPLC)
Synonym(s):
1-([1,1′-Biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one, 4-Amino-1-[1,1′-biphenyl]-3-yl-5-chloro-2(1H)-pyrimidinone
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About This Item
Empirical Formula (Hill Notation):
C16H12ClN3O
CAS Number:
Molecular Weight:
297.74
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
NC1=NC(N(C2=CC=CC(C3=CC=CC=C3)=C2)C=C1Cl)=O
Biochem/physiol Actions
Bobcat339 is a cell penetrant, potent and selective inhibitor of TET1 and TET2 [Ten-eleven translocation methylcytosine dioxygenase (TET) 1 and 2] that reduces content of 5-hydroxymethyl-cytosine (5hmC) in cultured neurons. Bobcat339 does not inhibit DNMT3a.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Gabriella N L Chua et al.
ACS medicinal chemistry letters, 10(2), 180-185 (2019-02-21)
DNA methylation is known as the prima donna epigenetic mark for its critical role in regulating local gene transcription. Changes in the landscape of DNA methylation across the genome occur during cellular transition, such as differentiation and altered neuronal plasticity
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