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SML2593

Sigma-Aldrich

MS0021570

≥98% (HPLC)

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Synonym(s):
5-(Benzylsulfanyl)-N-methyl-1,3,4-thiadiazol-2-amine, 5-(Benzylthio)-N-methyl-1,3,4-thiadiazol-2-amine, MS 21570, MS0021570_1, N-Methyl-5-[(phenylmethyl)thio]-1,3,4-thiazadiazol-2-amine
Empirical Formula (Hill Notation):
C10H11N3S2
CAS Number:
Molecular Weight:
237.34
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

MS0021570 is a potent antagonist of GPR171, a G protein-coupled receptor of BigLEN (b-LEN), which is a neuropeptide derived from proSAAS and involved in regulation of feeding. MS0021570 had a IC50 value of 220 nM. It was shown to block inceases in food intake and to reduce anxiety-like behavior and fear conditioning in mice.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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